Using targeted microparticles to help regenerate weakened muscles
Macrophage targeted microparticles for the regeneration of atrophied muscle
['FUNDING_OTHER'] · VETERANS HEALTH ADMINISTRATION · NIH-11083094
This study is testing a new treatment that uses tiny particles to deliver a special compound to help people with muscle weakness from being inactive due to injury or illness, aiming to improve their muscle strength and movement.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VETERANS HEALTH ADMINISTRATION (nih funded) |
| Locations | 1 site (COLUMBIA, UNITED STATES) |
| Trial ID | NIH-11083094 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a new treatment to help restore muscle function in individuals suffering from muscle atrophy, particularly due to inactivity from injury or illness. The approach involves using specially designed microparticles that deliver a compound called all-trans retinoic acid directly to the affected muscle tissue. By targeting macrophages, which play a crucial role in muscle repair and growth, this treatment aims to enhance muscle recovery and improve mobility. The study will assess the effectiveness of this treatment in restoring muscle size and function in patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults and veterans who have experienced muscle loss due to inactivity or age-related decline.
Not a fit: Patients with muscle atrophy due to non-age-related conditions or those who are not experiencing significant muscle weakness may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a novel therapy that significantly improves muscle recovery and function for patients experiencing muscle atrophy.
How similar studies have performed: Previous research has shown promising results with similar approaches targeting macrophages for muscle regeneration, indicating potential for success in this novel application.
Where this research is happening
COLUMBIA, UNITED STATES
- VETERANS HEALTH ADMINISTRATION — COLUMBIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOWER, ROBERT MICHAEL — VETERANS HEALTH ADMINISTRATION
- Study coordinator: GOWER, ROBERT MICHAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.