Using targeted delivery of antibody-releasing cells to manage HIV in the brain.
Image-guided intra-arterial administration of antibody-releasing glial progenitors to control the HIV CNS reservoir.
This study is exploring a new way to deliver special cells that can help fight HIV directly to the brain, which could improve treatment for people living with HIV and help reduce related cognitive issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10868579 on NIH RePORTER |
What this research studies
This research aims to develop a method for delivering antibody-releasing glial progenitor cells directly to the brain to control HIV reservoirs. The approach focuses on overcoming the challenges of the blood-brain barrier, which limits the effectiveness of current HIV treatments. By utilizing image-guided intra-arterial administration, the researchers hope to enhance the delivery of these therapeutic agents to the central nervous system, potentially reducing HIV replication and associated cognitive disorders. Patients living with HIV may benefit from this innovative treatment strategy, which seeks to address the limitations of existing antiretroviral therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV, particularly those experiencing cognitive, motor, or mood issues related to HIV-associated neurocognitive disorder.
Not a fit: Patients who are not living with HIV or those who do not have cognitive or neurological complications related to HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for controlling HIV in the brain and preventing related cognitive disorders.
How similar studies have performed: While the approach of using antibody-releasing cells is innovative, similar strategies targeting the brain for HIV treatment have shown promise in preliminary studies.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Walczak, Piotr — University of Maryland Baltimore
- Study coordinator: Walczak, Piotr
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.