Using targeted brain stimulation to improve memory in people with mild cognitive impairment
Network-targeted theta-burst stimulation for episodic memory improvement in mild cognitive impairment
This study is exploring a new way to help improve memory for people with mild cognitive impairment by using a gentle brain stimulation technique, hoping to boost how different parts of the brain work together and possibly delay Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10832475 on NIH RePORTER |
What this research studies
This research investigates a new method to enhance memory in individuals with amnestic mild cognitive impairment (aMCI) using a technique called theta burst transcranial magnetic stimulation (TBS). By applying this non-invasive stimulation to specific brain areas connected to memory, the study aims to improve hippocampal-cortical connectivity. Participants will undergo neuroimaging to tailor the treatment to their individual brain networks, potentially leading to better memory function and delaying the onset of Alzheimer's disease. The study also incorporates genetic testing and EEG to further understand the brain's response to treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are elderly individuals diagnosed with amnestic mild cognitive impairment, particularly those at risk for developing Alzheimer's disease.
Not a fit: Patients with advanced Alzheimer's disease or those without cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved memory function and a delay in the progression of Alzheimer's disease for individuals with mild cognitive impairment.
How similar studies have performed: Previous studies have shown promise in using non-invasive brain stimulation techniques for memory improvement, indicating potential success for this novel approach.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Leuchter, Andrew F — University of California Los Angeles
- Study coordinator: Leuchter, Andrew F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.