Using targeted brain stimulation to improve memory in early Alzheimer's disease
Using network-guided TMS to ameliorate memory deficits in early Alzheimer's disease
['FUNDING_R21'] · DUKE UNIVERSITY · NIH-10128788
This study is looking at how a special type of brain stimulation called TMS can help improve memory for people with early Alzheimer's disease by working on different parts of the brain at the same time.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10128788 on ClinicalTrials.gov |
What this research studies
This research investigates the use of transcranial magnetic stimulation (TMS) to enhance memory function in individuals with early Alzheimer's disease. By focusing on the brain's network control structure, the study aims to stimulate multiple brain regions simultaneously, potentially leading to improved cognitive outcomes. Participants will receive non-invasive brain stimulation aimed at increasing brain plasticity and enhancing cognitive functions that are typically impaired in Alzheimer's. The approach is novel as it considers the broader connectivity of brain areas rather than targeting a single region.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have been diagnosed with early Alzheimer's disease or mild cognitive impairment.
Not a fit: Patients with advanced Alzheimer's disease or those with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new non-pharmacological treatments that significantly improve memory and cognitive function in patients with early Alzheimer's disease.
How similar studies have performed: Previous studies have shown promising results using TMS in normative populations, but this approach targeting Alzheimer's-related cognitive decline is relatively novel and untested.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DAVIS, SIMON W — DUKE UNIVERSITY
- Study coordinator: DAVIS, SIMON W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer's Disease