Using targeted antibodies to treat gut microbiome issues linked to inflammation
Official title: Targeted Immunotherapeutics In Dysbiotic Microbiomes - A Feasibility and Proof-of-Concept Study
Funded at Evimero, LLC · NIH-11007922 · Data updated 2026-11-12
This study is looking at how special antibodies from hen eggs can help people with gut problems and inflammation by calming down harmful molecules in their gut, making it a friendly option for those dealing with microbiome-related issues.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Evimero, LLC NIH-funded |
| Lab location | 1 site (Tuscaloosa, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $325,139 |
| NIH project number | 1R43TR005333-01 |
| Project ID | NIH-11007922 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing gut inflammation and dysbiosis, particularly those with conditions like Alzheimer's disease or other microbiome-associated disorders.
✕Less likely to help
Patients without gut microbiome issues or those not experiencing inflammation may not benefit from this research.
What this research studies
This research investigates the use of specific antibodies to neutralize harmful molecules in the gut microbiome of individuals suffering from inflammation and compromised gut barrier function. By focusing on patients with dysbiotic microbiomes, the study aims to demonstrate how these antibodies can mitigate the negative effects of microbiome-related disorders. The approach involves extracting antibodies from the eggs of immunized hens, which are then tested for their ability to counteract inflammatory signals and restore gut health. Patients may be monitored for changes in gut health and inflammation levels throughout the process.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve gut health and reduce inflammation in patients with microbiome-related disorders.
How similar studies have gone: While the use of antibodies in microbiome research is a growing field, this specific approach of using polyclonal antibodies from hen eggs is relatively novel and has not been extensively tested in similar contexts.
Where this research is happening
-
Evimero, LLC
Tuscaloosa, United States Active
Researchers
- Principal investigator: Goepp, Julius G — Evimero, LLC
- Study coordinator: Goepp, Julius G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.