Using sulfated carbohydrates to treat gum disease
Official title: Sulfated Carbohydrates for the Treatment of Periodontitis
Funded at Glycan Therapeutics Corporation · NIH-10756240 · Data updated 2026-11-12
This study is looking at a new treatment for gum disease called periodontitis, especially for people with diabetes, by testing a special carbohydrate that might help reduce inflammation and improve bone health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Glycan Therapeutics Corporation NIH-funded |
| Lab location | 1 site (Raleigh, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $347,537 |
| NIH project number | 1R41DE032276-01A1 |
| Project ID | NIH-10756240 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults suffering from periodontitis, especially those with severe or hyperinflammatory forms of the disease, such as individuals with diabetes.
✕Less likely to help
Patients who do not have periodontitis or those with mild forms of gum disease may not benefit from this research.
What this research studies
This research investigates a new treatment for periodontitis, a common gum disease affecting many adults. The approach focuses on a specific type of carbohydrate, known as sulfated low molecular weight heparan sulfate, which has shown promise in reducing inflammation and promoting bone health. The research will involve both laboratory tests and studies in living subjects to assess the effectiveness of this carbohydrate in treating severe forms of periodontitis, particularly in individuals with diabetes. The team includes experts in periodontology and carbohydrate synthesis, aiming to develop a reliable therapeutic option for patients suffering from this condition.
Why it matters
Potential benefit: If successful, this research could provide a novel and effective treatment for periodontitis, improving oral health and quality of life for many patients.
How similar studies have gone: While the specific approach of using sulfated carbohydrates for periodontitis is novel, there is preliminary evidence suggesting that similar anti-inflammatory treatments have shown promise in other contexts.
Where this research is happening
-
Glycan Therapeutics Corporation
Raleigh, United States Active
Researchers
- Principal investigator: Miguez, Patricia — Glycan Therapeutics Corporation
- Study coordinator: Miguez, Patricia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.