Using sulfated carbohydrates to treat gum disease
Sulfated Carbohydrates for the Treatment of Periodontitis
This study is looking at a new treatment for gum disease called periodontitis, especially for people with diabetes, by testing a special carbohydrate that might help reduce inflammation and improve bone health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Glycan Therapeutics Corporation NIH-funded |
| Lab location | 1 site (Raleigh, UNITED STATES) |
| Project ID | NIH-10756240 on NIH RePORTER |
What this research studies
This research investigates a new treatment for periodontitis, a common gum disease affecting many adults. The approach focuses on a specific type of carbohydrate, known as sulfated low molecular weight heparan sulfate, which has shown promise in reducing inflammation and promoting bone health. The research will involve both laboratory tests and studies in living subjects to assess the effectiveness of this carbohydrate in treating severe forms of periodontitis, particularly in individuals with diabetes. The team includes experts in periodontology and carbohydrate synthesis, aiming to develop a reliable therapeutic option for patients suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults suffering from periodontitis, especially those with severe or hyperinflammatory forms of the disease, such as individuals with diabetes.
Not a fit: Patients who do not have periodontitis or those with mild forms of gum disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a novel and effective treatment for periodontitis, improving oral health and quality of life for many patients.
How similar studies have performed: While the specific approach of using sulfated carbohydrates for periodontitis is novel, there is preliminary evidence suggesting that similar anti-inflammatory treatments have shown promise in other contexts.
Where this research is happening
Raleigh, UNITED STATES
- Glycan Therapeutics Corporation — Raleigh, United States (Active)
Researchers
- Principal investigator: Miguez, Patricia — Glycan Therapeutics Corporation
- Study coordinator: Miguez, Patricia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.