Using stem cells to treat type 1 diabetes
Cellular Therapy for Type 1 Diabetes using Mesenchymal Stem Cells
This study is looking at how using special cells called mesenchymal stem cells might help people with type 1 diabetes by calming the immune system and helping the body make more insulin, with the hope of improving their blood sugar levels and overall health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-11089333 on NIH RePORTER |
What this research studies
This research investigates the use of mesenchymal stem cells (MSCs) to address two major challenges in curing type 1 diabetes: the autoimmune response and the destruction of insulin-producing cells. By infusing MSCs, which have both immune-modulating and regenerative properties, the study aims to reduce hyperglycemia and promote the regeneration of insulin-secreting cells. The approach builds on previous findings in animal models and early clinical trials, exploring the potential for MSCs to improve patient outcomes in type 1 diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with new-onset type 1 diabetes who are experiencing challenges with insulin production.
Not a fit: Patients with long-standing type 1 diabetes or those who do not respond to conventional treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that help preserve insulin production and improve blood sugar control in patients with type 1 diabetes.
How similar studies have performed: Previous studies have shown promising results with MSCs in treating autoimmune diseases, indicating potential for success in this novel application for type 1 diabetes.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Wang, Hongjun — Medical University of South Carolina
- Study coordinator: Wang, Hongjun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.