Using stem cells to treat severe bowel disease in newborns
Sulfur Based Stem Cell Therapeutics in Necrotizing Enterocolitis
This study is looking at a new way to help premature babies with necrotizing enterocolitis (NEC) by using special cells to boost healing in their intestines and improve their chances of recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11042845 on NIH RePORTER |
What this research studies
This research focuses on developing a new treatment for necrotizing enterocolitis (NEC), a serious condition affecting premature infants that can lead to the need for intestinal surgery. The study investigates the use of mesenchymal stem cells derived from induced pluripotent stem cells, aiming to harness the protective effects of hydrogen sulfide in the intestines. Researchers will create a specialized probe to measure hydrogen sulfide levels and explore how it can improve blood flow and healing in the intestines. The goal is to enhance the survival and health of infants suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are premature infants diagnosed with necrotizing enterocolitis.
Not a fit: Patients who are not premature or do not have necrotizing enterocolitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve survival rates and health outcomes for infants with necrotizing enterocolitis.
How similar studies have performed: While cellular therapies for NEC are still emerging, there is growing evidence that similar approaches using stem cells have shown promise in other conditions.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Markel, Troy a — Indiana University Indianapolis
- Study coordinator: Markel, Troy a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.