Using stem cells to treat dry mouth caused by radiation therapy
Mesenchymal stromal cells for treatment of radiation-induced xerostomia
This study is looking at how special cells called mesenchymal stromal cells might help people who have dry mouth after radiation treatment for head and neck cancer, with the goal of making their salivary glands work better and improving their overall comfort and quality of life.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10849890 on NIH RePORTER |
What this research studies
This research investigates the use of mesenchymal stromal cells (MSCs) to alleviate radiation-induced xerostomia, a common and debilitating condition affecting patients who have undergone radiation therapy for head and neck cancers. The study aims to understand how MSCs can improve salivary gland function and reduce the perception of dry mouth. By exploring the mechanisms behind MSC therapy and identifying the best sources of these cells, the research seeks to develop a safe and effective treatment that enhances patients' quality of life. The approach includes both short-term and long-term assessments of MSC effects on salivary function.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have received radiation therapy for head and neck cancers and are experiencing symptoms of dry mouth.
Not a fit: Patients who have not undergone radiation therapy or do not experience xerostomia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a novel and effective treatment option for patients suffering from dry mouth due to radiation therapy.
How similar studies have performed: Previous small studies have shown promise in using MSC therapy for similar conditions, indicating potential for success in this approach.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Paz, Cristina — University of Wisconsin-Madison
- Study coordinator: Paz, Cristina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.