Using stem cells to replace lost nerve cells in the eye to restore vision.
Transplantation of human stem cell-derived neurons for retinal ganglion cell replacement and optic nerve regeneration.
This study is exploring a new way to help people with vision loss from conditions like glaucoma by using special cells made from stem cells to replace damaged ones in the eye, with the hope of restoring their sight.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10915637 on NIH RePORTER |
What this research studies
This research focuses on developing a method to replace damaged retinal ganglion cells (RGCs) in the eye using stem cell-derived neurons. The approach involves generating these neurons in the lab and transplanting them into the eye to potentially regenerate the optic nerve and restore vision lost due to conditions like glaucoma. The study aims to enhance the survival of these transplanted cells and improve their integration with existing retinal neurons, which is crucial for effective communication within the visual system. By addressing these challenges, the research seeks to provide a new therapeutic avenue for patients suffering from optic neuropathies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from optic neuropathies, particularly those with glaucoma-related vision loss.
Not a fit: Patients with non-neurodegenerative vision issues or those whose optic nerves are intact may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that restore vision for patients with optic nerve damage.
How similar studies have performed: While stem cell therapies for neurodegenerative diseases are being explored, this specific approach to optic nerve regeneration is novel and has not been extensively tested in clinical settings.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Johnson, Thomas Vincent — Johns Hopkins University
- Study coordinator: Johnson, Thomas Vincent
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.