Using stem cells to repair damaged spinal cords
Reconnecting the injured cervical spinal cord by transplanted human iPSC-derived neural progenitors
This study is exploring whether special cells made from your own stem cells can help repair damaged areas of the neck spinal cord, with the hope that they can help restore movement and feeling after an injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project ID | NIH-10614660 on NIH RePORTER |
What this research studies
This research investigates the potential of using neural progenitor cells derived from patients' own induced pluripotent stem cells (iPSCs) to reconnect injured areas of the cervical spinal cord. The approach involves transplanting both glial restricted progenitors and neuronal restricted progenitors to form neuronal relays that can restore communication between damaged nerve pathways. The study aims to determine if these transplanted cells can integrate into existing circuits and promote functional recovery in animal models of spinal cord injury. By understanding how these cells interact and function, the research hopes to pave the way for new treatments for spinal cord injuries in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have suffered cervical spinal cord injuries and are seeking potential new treatment options.
Not a fit: Patients with spinal cord injuries that are not cervical or those who are not eligible for stem cell therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that significantly improve recovery and quality of life for patients with spinal cord injuries.
How similar studies have performed: Other research has shown promise in using stem cell therapies for spinal cord injuries, indicating that this approach could be a viable option.
Where this research is happening
Miami, United States
- Florida International University — Miami, United States (Active)
Researchers
- Principal investigator: Liu, Ying — Florida International University
- Study coordinator: Liu, Ying
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.