Using stem cells to regenerate liver tissue
A multi-modular approach for human pluripotent stem cell-based liver regeneration
['FUNDING_R01'] · BOSTON MEDICAL CENTER · NIH-10670221
This study is exploring a new way to help people with liver diseases by using special stem cells to create healthy liver cells that can fix damaged tissue, which could be a great option for those waiting for a liver transplant or dealing with long-term liver issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10670221 on ClinicalTrials.gov |
What this research studies
This research investigates a new approach to treat liver diseases by using human induced pluripotent stem cells (hiPSCs) to create liver cells that can replace damaged tissue. The project aims to overcome challenges in cell therapy, such as poor cell integration and maturation, by combining liver cells with supportive endothelial cells. By engineering these cells with advanced genetic technology, the researchers hope to enhance their ability to repair the liver. This innovative method could provide a solution for patients awaiting liver transplants or those with chronic liver conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with acute or chronic liver failure who may benefit from liver cell replacement therapies.
Not a fit: Patients with liver diseases that are not amenable to cell replacement therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for liver diseases, potentially reducing the need for liver transplants.
How similar studies have performed: Previous research has shown promise in using stem cells for tissue regeneration, but this specific multi-modular approach is relatively novel.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOUON-EVANS, VALERIE B — BOSTON MEDICAL CENTER
- Study coordinator: GOUON-EVANS, VALERIE B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.