Using stem cells to regenerate blood vessels in the eye for treating blindness
Embryonic vascular stem-progenitors for treatment of ischemic retinopathies
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-10771978
This study is looking at how special stem cells from embryos can help grow new blood vessels in the eye to improve vision for people with conditions like branch vein occlusion and diabetic retinopathy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10771978 on ClinicalTrials.gov |
What this research studies
This research investigates the potential of using embryonic vascular stem-progenitors to regenerate blood vessels in the eye, specifically targeting conditions like branch vein occlusion and diabetic retinopathy that can lead to blindness. The approach involves transplanting patient-specific stem cells derived from induced pluripotent stem cells, which are modified to enhance their regenerative capabilities. By focusing on these specialized cells, the research aims to restore blood flow and improve vision in affected patients. The study also explores innovative methods to revert stem cells to a more primitive state, enhancing their effectiveness in treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with branch vein occlusion or diabetic retinopathy who are at risk of vision loss.
Not a fit: Patients with non-vascular related eye conditions or those who do not have ischemic retinopathies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a novel treatment option that restores vision and prevents blindness in patients suffering from ischemic retinopathies.
How similar studies have performed: Previous research has shown promising results using similar stem cell approaches for vascular regeneration, indicating potential for success in this novel application.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZAMBIDIS, ELIAS T. — JOHNS HOPKINS UNIVERSITY
- Study coordinator: ZAMBIDIS, ELIAS T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.