Using stem cells to preserve joints and reduce pain
Official title: Stem cell reprogramming for joint preservation to alleviate pain and promote function
Funded at Veterans Health Administration · NIH-10996243 · Data updated 2026-11-12
This study is looking at a new way to help veterans with osteoarthritis by using special cells to reduce joint pain and improve healing, so they can feel better without relying on painkillers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Decatur, UNITED STATES) |
| Project start | October 1, 2024 |
| Project end | September 30, 2028 |
| Funding year | 2025 |
| NIH project number | 1I01RX005322-01 |
| Project ID | NIH-10996243 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans diagnosed with osteoarthritis, particularly those who have experienced joint injuries.
✕Less likely to help
Patients who do not have osteoarthritis or those with other unrelated joint conditions may not benefit from this research.
What this research studies
This research aims to develop a method for preserving joint tissue and alleviating pain in veterans suffering from osteoarthritis (OA) by using immunomodulatory cells. The approach involves injecting these cells into the joints to promote healing and function, particularly in those who may have experienced joint injuries during military service. The study builds on previous findings that suggest certain types of stem cells can be more effective in treating OA pain. By focusing on veterans, the research addresses a critical need for effective pain management strategies that avoid the long-term risks associated with opioid use.
Why it matters
Potential benefit: If successful, this research could provide veterans with a new treatment option that alleviates joint pain and improves mobility without the risks of traditional pain medications.
How similar studies have gone: Previous studies have shown promising results using mesenchymal stromal cells for treating osteoarthritis, indicating that this approach has potential based on existing evidence.
Where this research is happening
-
Veterans Health Administration
Decatur, United States Active
Researchers
- Principal investigator: Drissi, Moulay Hicham — Veterans Health Administration
- Study coordinator: Drissi, Moulay Hicham
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.