Using stem cells to eliminate HIV in a model of the disease
"Corral and Kill" strategy for HIV eradication using MSC in an SIV model
['FUNDING_R37'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-10996270
This study is exploring a new way to help people with HIV by using special cells from the body to boost the immune system's ability to fight the virus, which could lead to better treatments in the future.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-10996270 on ClinicalTrials.gov |
What this research studies
This research investigates a novel approach to eradicate HIV by utilizing mesenchymal stem cells (MSCs) in a simian immunodeficiency virus (SIV) model. The study aims to understand how these stem cells can be harnessed to enhance the immune response against the virus, potentially leading to a functional cure for HIV. By employing advanced techniques in adoptive T cell transfer, the research seeks to improve the body's ability to fight off the virus and prevent its reactivation. Patients may benefit from insights gained in this model that could translate into new therapies for HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are seeking innovative treatment options.
Not a fit: Patients who are not infected with HIV or those who have advanced AIDS may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to groundbreaking treatments that effectively eliminate HIV from the body.
How similar studies have performed: While the approach of using stem cells for HIV eradication is promising, it remains largely untested in human subjects, making this research a novel endeavor.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DANDEKAR, SATYA — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: DANDEKAR, SATYA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome Virus