Using stem cells to create muscle cells for treating muscular dystrophy
Preclinical studies of pluripotent stem cell-derived myogenic progenitors in non-human primates
This study is exploring how special stem cells can be turned into muscle-building cells to help improve muscle function in people with Duchenne Muscular Dystrophy (DMD) by testing them in monkeys, with the hope of finding new ways to help those with muscle loss feel better and live healthier lives.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10897092 on NIH RePORTER |
What this research studies
This research investigates the use of pluripotent stem cells to generate myogenic progenitors, which are cells that can develop into muscle cells, specifically targeting conditions like Duchenne Muscular Dystrophy (DMD). The approach involves creating these progenitors through a specific genetic method and then testing their ability to regenerate muscle tissue in non-human primates. By transplanting these cells, the research aims to restore muscle function and improve the quality of life for individuals affected by muscle degeneration. The study focuses on understanding how these cells can integrate into existing muscle tissue and respond to injury.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with muscular dystrophies, particularly those with Duchenne Muscular Dystrophy.
Not a fit: Patients with muscular dystrophies caused by non-genetic factors or those who are not responsive to cell-based therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve muscle regeneration and function in patients with muscular dystrophies.
How similar studies have performed: Previous research has shown promising results in using stem cell therapies for muscle regeneration, indicating potential success for this approach.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Perlingeiro, Rita C. R. — University of Minnesota
- Study coordinator: Perlingeiro, Rita C. R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.