Using stem cells from salivary glands to prevent dry mouth after radiation therapy
Planning a phase I study of minor salivary gland derived autologous MSCs for prevention of long-term radiation induced xerostomia
This study is looking at a new treatment to help people with dry mouth caused by radiation therapy for head and neck cancer, using special cells from their own saliva glands to see if it can improve their saliva production and overall quality of life.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10910120 on NIH RePORTER |
What this research studies
This research focuses on addressing dry mouth, a common and debilitating side effect experienced by patients undergoing radiation therapy for head and neck cancer. The study aims to explore the use of autologous mesenchymal stromal cells (MSCs) derived from minor salivary glands to prevent long-term salivary gland dysfunction. By planning a Phase I trial, the researchers will assess the safety and effectiveness of this innovative cellular therapy. Patients may benefit from improved salivary function and quality of life if the treatment proves successful.
Who could benefit from this research
Good fit: Ideal candidates for this research are head and neck cancer patients who are undergoing or have undergone radiation therapy and are experiencing symptoms of dry mouth.
Not a fit: Patients who do not have head and neck cancer or who have not received radiation therapy are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the quality of life for patients suffering from dry mouth due to radiation therapy.
How similar studies have performed: While the use of cellular therapies for salivary gland dysfunction is an emerging field, similar approaches have shown promise in preliminary studies, indicating potential for success.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Kimple, Randall J. — University of Wisconsin-Madison
- Study coordinator: Kimple, Randall J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.