Using stem cell-derived vesicles to enhance brain function in older adults
Neural Stem Cell-derived EVs for Improving Aged Brain Function
['FUNDING_R01'] · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · NIH-11088781
This study is exploring a new treatment using tiny particles from human stem cells to help boost memory and thinking skills in older adults, and it involves giving these particles through the nose to see if they can make the brain healthier and reduce inflammation.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR (nih funded) |
| Locations | 1 site (COLLEGE STATION, UNITED STATES) |
| Trial ID | NIH-11088781 on ClinicalTrials.gov |
What this research studies
This research investigates a new therapy using extracellular vesicles (EVs) derived from human stem cells to improve cognitive and memory functions in older adults. The approach involves administering these vesicles intranasally to target the brain, aiming to reduce inflammation and promote neurogenesis. By studying their effects in a mouse model, the research seeks to understand how these vesicles can activate beneficial pathways in the brain, potentially leading to improved cognitive health in aging populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who may be experiencing cognitive decline.
Not a fit: Patients under the age of 65 or those without cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that enhance cognitive function and memory in older adults.
How similar studies have performed: Preliminary studies have shown promise in using similar approaches with stem cell-derived therapies to improve cognitive function in aging models.
Where this research is happening
COLLEGE STATION, UNITED STATES
- TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR — COLLEGE STATION, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHETTY, ASHOK K — TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
- Study coordinator: SHETTY, ASHOK K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.