Using stem cell-derived exosomes to improve cognitive function after chemotherapy
Official title: Stem cell-derived exosomes to ameliorate chemobrain
Funded at University of California-Irvine · NIH-11039931 · Data updated 2026-11-12
This study is looking at how tiny particles from human brain cells might help improve thinking and memory problems caused by chemotherapy, aiming to find a way to make life better for cancer survivors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | March 13, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $359,138 |
| NIH project number | 5R01CA262213-03 |
| Project ID | NIH-11039931 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have experienced cognitive issues following chemotherapy for cancer.
✕Less likely to help
Patients who have not undergone chemotherapy or those with pre-existing severe cognitive impairments unrelated to cancer treatment may not benefit from this research.
What this research studies
This research investigates the use of exosomes derived from human neural stem cells to address cognitive impairments caused by chemotherapy, commonly referred to as chemobrain. The study aims to understand how these exosomes can reduce neuroinflammation and improve cognitive function in cancer survivors. By focusing on the long-term effects of chemotherapy on brain health, the research seeks to develop a potential treatment that could enhance the quality of life for patients who have undergone cancer therapy. Patients participating in this research may receive treatment with these exosomes to evaluate their effectiveness in reversing cognitive deficits.
Why it matters
Potential benefit: If successful, this research could provide a novel treatment option to alleviate cognitive impairments in cancer survivors, significantly improving their quality of life.
How similar studies have gone: Other research has shown promise in using stem cell-derived therapies for cognitive impairments, suggesting that this approach may be viable.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Acharya, Munjal M — University of California-Irvine
- Study coordinator: Acharya, Munjal M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.