Using statins to prevent dementia in older adults
PREVENTABLE Recruitment and Retention
This study is looking at whether taking moderate doses of statin medication can help prevent dementia, like Alzheimer's, in people aged 75 and older who don’t have heart disease, and it aims to include a diverse group of 20,000 participants from across the U.S.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10913411 on NIH RePORTER |
What this research studies
This research investigates whether moderate-intensity statin therapy can help prevent dementia, including Alzheimer's disease, in individuals aged 75 and older who do not have evident coronary heart disease. The study aims to enroll 20,000 participants across the United States, focusing on diverse groups including women, racial and ethnic minorities, and those with frailty or cognitive impairment. It addresses challenges in recruiting older adults for clinical trials, such as perceived burdens and logistical issues, to ensure a robust and representative participant pool.
Who could benefit from this research
Good fit: Ideal candidates are individuals aged 75 and older without clinically evident coronary heart disease, particularly those with frailty, cognitive impairment, or multiple health conditions.
Not a fit: Patients under 75 years old or those with clinically evident coronary heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new preventive strategies for dementia, potentially improving the quality of life for older adults.
How similar studies have performed: Previous research has shown promise in using statins for cardiovascular health, but this specific approach to dementia prevention is novel and untested.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Jones, William S — Duke University
- Study coordinator: Jones, William S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.