Using spermidine to treat colitis and prevent related cancers
Spermidine as a New Therapy for Colitis and Chemopreventive for Colitis-associated Carcinogenesis
This study is looking at how spermidine, a natural compound, might help people with inflammatory bowel disease (IBD) feel better and lower their chances of getting certain cancers, with hopes of leading to future treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10795021 on NIH RePORTER |
What this research studies
This research investigates the potential of spermidine, a naturally occurring compound, as a new treatment for inflammatory bowel disease (IBD) and as a preventive measure against colitis-associated cancers. The study aims to explore how spermidine can improve the health of patients with IBD by enhancing their quality of life and reducing cancer risks. Researchers will utilize advanced mass spectrometry techniques to measure polyamine levels and assess the effectiveness of spermidine supplementation in preclinical models. The ultimate goal is to gather insights that will pave the way for future clinical trials involving human participants.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with inflammatory bowel disease, particularly those experiencing ulcerative colitis.
Not a fit: Patients who do not have inflammatory bowel disease or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a safe and effective new therapy for patients suffering from colitis and reduce their risk of developing associated cancers.
How similar studies have performed: Previous studies have shown promising results with spermidine supplementation in early clinical trials, indicating potential for success in this area.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Wilson, Keith T. — Vanderbilt University Medical Center
- Study coordinator: Wilson, Keith T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.