Using specific molecules to detect head and neck cancer from oral rinses
Aptamer specific for myeloid derived suppressor cells for the diagnosis of head and neck cancer from the oral rinse
['FUNDING_R21'] · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · NIH-10802445
This study is working on a new way to help catch head and neck cancer early by looking at samples from mouth rinses, using special tools to find cancer-related cells, so that people can get diagnosed more accurately and quickly.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MIAMI SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (CORAL GABLES, UNITED STATES) |
| Trial ID | NIH-10802445 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a new diagnostic method for early detection of head and neck cancer by analyzing oral rinses. It utilizes RNA aptamers that specifically target myeloid-derived suppressor cells, which are present in high numbers in tumors and can indicate the presence of cancer. The study aims to improve the sensitivity of cancer detection by distinguishing between cancerous and healthy cells in the oral rinse samples. By employing advanced techniques like linear surface plasmon resonance, the researchers hope to create a reliable test for identifying head and neck squamous cell carcinoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk for or have been diagnosed with head and neck cancer.
Not a fit: Patients with other types of cancers or those without any cancer risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a more accurate and non-invasive method for diagnosing head and neck cancer at an earlier stage.
How similar studies have performed: Previous research has shown promise in using similar biomarker approaches for cancer detection, indicating potential success for this novel method.
Where this research is happening
CORAL GABLES, UNITED STATES
- UNIVERSITY OF MIAMI SCHOOL OF MEDICINE — CORAL GABLES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SERAFINI, PAOLO — UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- Study coordinator: SERAFINI, PAOLO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers