Using specific cells to help regenerate periodontal tissue
Harnessing PRX1 expressing cells for endogenous periodontal regeneration
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11167625
This study is looking at special cells that can help heal gum tissue damaged by periodontal disease, with the hope of finding better treatments for people dealing with this common dental issue.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11167625 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how certain cells, known as PRX1-expressing periodontal ligament stem cells, can be harnessed to regenerate periodontal tissue lost due to periodontal disease. By utilizing advanced techniques like single-cell RNA sequencing, the researchers aim to uncover the biological mechanisms that enable these cells to promote tissue regeneration. The goal is to develop more effective therapies for patients suffering from periodontal disease, which is a significant global health issue linked to other serious conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from periodontal disease who are experiencing tissue loss and related complications.
Not a fit: Patients with healthy periodontal tissue or those not affected by periodontal disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that restore periodontal health and prevent tooth loss for patients with periodontal disease.
How similar studies have performed: Previous research has shown promise in using stem cells for tissue regeneration, indicating that this approach could lead to significant advancements in periodontal therapy.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: INTINI, GIUSEPPE — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: INTINI, GIUSEPPE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.