Using specialized lipids to enhance stem cell therapy for gum tissue regeneration
Specialized Proresolving Lipid Mediator-Enhanced Stem Cell Therapy and Tissue Regeneration
['FUNDING_OTHER'] · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · NIH-11196342
This study is looking at how a special substance called Maresin 1 can help improve stem cell therapy for healing gum tissues damaged by long-term inflammation, and it's designed for people with periodontal disease.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCIENCE CENTER (nih funded) |
| Locations | 1 site (SAN ANTONIO, UNITED STATES) |
| Trial ID | NIH-11196342 on ClinicalTrials.gov |
What this research studies
This research investigates how specialized lipid mediators can improve stem cell therapy aimed at regenerating periodontal tissues affected by chronic inflammation. By focusing on a specific lipid called Maresin 1, the study aims to understand its role in promoting healing and tissue regeneration in periodontal disease. The researchers will utilize advanced techniques, including RNA sequencing and metabolipidomics, to explore the mechanisms by which MaR1 enhances the regenerative properties of human periodontal ligament stem cells. The research will be conducted using a large animal model to ensure the findings can be effectively translated to human applications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from periodontal disease who have not responded well to conventional treatments.
Not a fit: Patients with advanced periodontal disease requiring surgical intervention or those with systemic conditions affecting healing may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for periodontal disease, improving oral health and quality of life for patients.
How similar studies have performed: Previous research has shown promise in using lipid mediators for inflammation resolution and tissue regeneration, indicating a potential for success in this novel approach.
Where this research is happening
SAN ANTONIO, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCIENCE CENTER — SAN ANTONIO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAKIAN, AUDREY — UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
- Study coordinator: RAKIAN, AUDREY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.