Using special polymers to reduce pancreatic cancer spread
Utilizing nucleic acid scavengers to elucidate how DNA/RNA-containing DAMPs promote pancreatic cancer metastasis and to mitigate such processes
This study is looking at a new way to help people with pancreatic cancer by using special polymers that can grab onto harmful molecules released during treatment, which might help stop cancer cells from spreading and make the treatment work better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11089609 on NIH RePORTER |
What this research studies
This research focuses on developing nucleic acid binding polymers that can capture and neutralize harmful molecules released during pancreatic cancer treatment. These molecules, known as Damage Associated Molecular Patterns (DAMPs), can promote cancer cell migration and metastasis. By administering these polymers alongside chemotherapy or surgery, the goal is to limit the cancer cells' ability to spread and improve treatment outcomes. The research builds on previous findings that suggest controlling inflammation can help manage cancer progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing chemotherapy or surgery for pancreatic cancer.
Not a fit: Patients with pancreatic cancer who are not receiving chemotherapy or surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for pancreatic cancer by reducing the spread of the disease.
How similar studies have performed: Previous studies have shown promise in using similar approaches to mitigate cancer metastasis, indicating potential for success in this research.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Sullenger, Bruce Alan — Duke University
- Study coordinator: Sullenger, Bruce Alan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.