Using special immune cells to fight HIV reservoirs
Harnessing Stem-Like CD8 T Cells for Immunotherapies to Eradicate HIV Reservoirs
This study is looking at a new way to help people living with HIV by using special immune cells to target and get rid of hidden HIV in their bodies, so they might not need to take medication all the time.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10874771 on NIH RePORTER |
What this research studies
This research focuses on developing a new immunotherapy approach to eliminate HIV reservoirs in patients who are currently on antiretroviral therapy. It aims to harness a specific type of immune cell, known as stem-like CD8 T cells, which have the potential to maintain long-term control of HIV without the need for continuous medication. The study will explore how these cells can be activated and enhanced to effectively target and eradicate latent HIV-infected cells. By understanding the mechanisms that allow these immune cells to function better, the research hopes to provide a more effective treatment option for HIV patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy and are interested in exploring new treatment options.
Not a fit: Patients who are not living with HIV or those who have advanced AIDS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a functional cure for HIV, allowing patients to maintain viral control without lifelong antiretroviral therapy.
How similar studies have performed: Previous research has shown promise in using T-cell based therapies for HIV, but this specific approach utilizing stem-like CD8 T cells is relatively novel.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Yao, Chen — Ut Southwestern Medical Center
- Study coordinator: Yao, Chen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.