Using special antibodies to improve the diagnosis and treatment of colon cancer
Official title: BCCMA: VA Colorectal Cancer Clinical & Computational Collaborative (VA-5C): NIR-labeled antibodies to target and label colon polyps and cancer for improved diagnosis and surgery
Funded at VA San Diego Healthcare System · NIH-10914722 · Data updated 2026-11-12
This study is working on a special dye that helps doctors see colon polyps and cancer cells more clearly, making it easier to diagnose and treat colorectal cancer, so patients can get better care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA San Diego Healthcare System NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | October 1, 2024 |
| Project end | September 30, 2028 |
| Funding year | 2025 |
| NIH project number | 1I01CX002707-01A1 |
| Project ID | NIH-10914722 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for colorectal cancer, including those with a history of polyps or family history of the disease.
✕Less likely to help
Patients who do not have colorectal cancer or precancerous polyps may not receive any benefit from this research.
What this research studies
This research focuses on developing a fluorescent antibody that targets and labels colon polyps and cancer cells to enhance the accuracy of diagnosis and treatment for colorectal cancer. By utilizing near-infrared (NIR) technology, the antibodies can provide clearer imaging of tumors, allowing for better detection and surgical resection. The study aims to conduct experiments that will prepare these antibodies for clinical use, potentially leading to improved patient outcomes. The approach has shown promise in preclinical models, indicating its potential effectiveness in real-world applications.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and better surgical outcomes for patients with colorectal cancer.
How similar studies have gone: Previous studies have shown success with similar antibody-targeting approaches in preclinical models, suggesting a promising avenue for clinical application.
Where this research is happening
-
VA San Diego Healthcare System
San Diego, United States Active
Researchers
- Principal investigator: Bouvet, Michael — VA San Diego Healthcare System
- Study coordinator: Bouvet, Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.