Using special agents to enhance the effectiveness of bone marrow stem cells for treating osteoarthritis
Official title: The Use of Senolytic and Anti-Fibrotic Agents to Improve the Beneficial Effect of Bone Marrow Stem Cells for Osteoarthritis
Funded at Steadman Philippon Research Institute · NIH-10913314 · Data updated 2026-11-12
This study is looking at how mixing special treatments with bone marrow stem cells might help people with osteoarthritis feel better and heal their joints more effectively.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Steadman Philippon Research Institute NIH-funded |
| Lab location | 1 site (Vail, United States) |
| Project start | August 1, 2020 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $551,586 |
| NIH project number | 5UH3AR077748-05 |
| Project ID | NIH-10913314 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are experiencing osteoarthritis.
✕Less likely to help
Patients with osteoarthritis who are not eligible for stem cell therapy or those with advanced joint degeneration may not benefit from this research.
What this research studies
This research investigates how combining senolytic and anti-fibrotic agents with bone marrow stem cells (BMSCs) can improve treatment outcomes for osteoarthritis (OA). Osteoarthritis is a painful joint condition that leads to cartilage damage and loss of function. The study aims to eliminate senescent cells that hinder stem cell function and to reduce fibrosis, which can impair cartilage repair. By enhancing the effectiveness of BMSCs, the research seeks to provide a more effective treatment option for patients suffering from OA.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for osteoarthritis, potentially reducing pain and restoring joint function for patients.
How similar studies have gone: Previous research has shown promise in using senolytic agents to delay osteoarthritis in preclinical models, indicating potential for success in this approach.
Where this research is happening
-
Steadman Philippon Research Institute
Vail, United States Active
Researchers
- Principal investigator: Huard, Johnny — Steadman Philippon Research Institute
- Study coordinator: Huard, Johnny
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.