Using soundwaves and stem cells to treat kidney injury
Treating Kidney Injury by Modulating Heat Shock Proteins Using Soundwaves Combined with Mesenchymal Stem Cells and Their Extracellular Vesicles
This study is exploring a new way to help people with acute kidney injury by using special cells and tiny particles from those cells, delivered directly to the injured kidneys using soundwaves, to see if this can better heal and protect the kidneys.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10902020 on NIH RePORTER |
What this research studies
This research investigates a novel approach to treat acute kidney injury (AKI) by using mesenchymal stem cells (MSCs) and their extracellular vesicles, delivered directly to the injured kidney using soundwaves. The goal is to enhance the effectiveness of MSC therapies, which have shown promise in preclinical models but face challenges in clinical application due to poor delivery methods. By optimizing the delivery of these therapies, the research aims to protect and regenerate damaged kidney cells, potentially reversing the progression of AKI. Patients may benefit from this innovative treatment if it proves successful in clinical settings.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals diagnosed with acute kidney injury who have not responded to conventional treatments.
Not a fit: Patients with chronic kidney disease or those who do not have acute kidney injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new therapeutic option for patients suffering from acute kidney injury, potentially improving kidney function and survival rates.
How similar studies have performed: While MSC therapies have shown promise in preclinical studies, this specific approach of using soundwaves for targeted delivery is novel and has not been extensively tested in clinical settings.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Thakor, Avnesh Sinh — Stanford University
- Study coordinator: Thakor, Avnesh Sinh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.