Using sound waves to improve cell engineering for cancer treatment
Acoustic microvortices instrumentation for dosage controlled, high efficiency cell engineering
This study is testing a new way to improve cancer-fighting immune cells called CAR T cells, using sound waves to help make them safer and more effective for patients, especially those who might benefit from treatments made from healthy donors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11089522 on NIH RePORTER |
What this research studies
This research focuses on developing a new technology called Acoustic-Electric Shear Orbiting Poration (AESOP) to enhance the engineering of immune cells, specifically CAR T cells, for cancer therapy. By utilizing acoustic microvortices, the approach aims to deliver genetic modifications to these cells in a controlled manner, improving their effectiveness and safety compared to traditional methods. The goal is to create universal CAR T cells that can be derived from healthy donors, minimizing the risk of immune rejection. Patients may benefit from more effective and safer cancer treatments as a result of this innovative technology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers that may be treated with CAR T cell therapies.
Not a fit: Patients who do not have cancer or those whose cancers are not suitable for CAR T cell therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective cancer immunotherapies for patients.
How similar studies have performed: Previous research in gene editing and nonviral transfection methods has shown promise, indicating that this approach could be a significant advancement in the field.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Lee, Abraham P — University of California-Irvine
- Study coordinator: Lee, Abraham P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.