Using sound to enhance memory during sleep in a mouse model of Alzheimer's disease
Official title: Holographic activation of ensemble activity during sleep in a mouse model of Alzheimer's disease
Funded at Icahn School of Medicine at Mount Sinai · NIH-10785393 · Data updated 2026-11-12
This study is looking at whether playing sounds while mice sleep can help them remember things better, which could lead to new ways to support people with Alzheimer's in improving their memory.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $132,705 |
| NIH project number | 1K99AG084853-01 |
| Project ID | NIH-10785393 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those experiencing significant memory decline.
✕Less likely to help
Patients without Alzheimer's disease or those who do not experience memory issues may not benefit from this research.
What this research studies
This research investigates how auditory stimulation during sleep can improve memory consolidation in a mouse model of Alzheimer's disease. The study focuses on the brain's ability to reactivate memories during slow-wave sleep, which is often disrupted in Alzheimer's patients. By using advanced techniques like 2-photon microscopy, the researchers aim to observe the effects of sound on brain activity and memory retention. The ultimate goal is to understand if enhancing memory reactivation during sleep can lead to better memory outcomes for those affected by Alzheimer's.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve memory retention in Alzheimer's patients.
How similar studies have gone: Previous studies have shown that auditory stimulation during sleep can enhance memory retention, suggesting a promising avenue for further exploration in Alzheimer's treatment.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Lines, Justin — Icahn School of Medicine at Mount Sinai
- Study coordinator: Lines, Justin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.