Using smell tests to identify Alzheimer's disease early
Olfactory Phenotypes as Non-Invasive Biomarkers for Alzheimer's Disease: A Machine Learning Approach
['FUNDING_R01'] · UNIVERSITY OF KANSAS MEDICAL CENTER · NIH-11049037
This study is looking at how problems with smelling can help us spot early signs of Alzheimer's disease, even in people who don’t have symptoms yet, using a fun and easy smell test with essential oils.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KANSAS MEDICAL CENTER (nih funded) |
| Locations | 1 site (KANSAS CITY, UNITED STATES) |
| Trial ID | NIH-11049037 on ClinicalTrials.gov |
What this research studies
This research investigates how olfactory dysfunction, or problems with the sense of smell, can serve as a non-invasive biomarker for Alzheimer's disease. By employing a machine learning approach, the study aims to develop a reliable and accessible method for detecting early signs of Alzheimer's, even in asymptomatic individuals. Participants will undergo olfactory testing using the Affordable Rapid Olfactory Measurement Array (AROMA), which utilizes essential oils to better mimic real-world scent recognition. The goal is to enhance early diagnosis and improve care planning for those at risk of Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who may be experiencing olfactory dysfunction or are concerned about their risk for Alzheimer's disease.
Not a fit: Patients under the age of 65 or those without any olfactory dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate identification of individuals at risk for Alzheimer's disease, allowing for timely interventions.
How similar studies have performed: Previous research has shown promise in using olfactory tests as biomarkers for Alzheimer's, indicating that this approach has potential for success.
Where this research is happening
KANSAS CITY, UNITED STATES
- UNIVERSITY OF KANSAS MEDICAL CENTER — KANSAS CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VILLWOCK, JENNIFER — UNIVERSITY OF KANSAS MEDICAL CENTER
- Study coordinator: VILLWOCK, JENNIFER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.