Using small molecules to help repair nerve injuries
Official title: Mid-sized GDNF Minics for Neural regeneration
Funded at Texas A&m University · NIH-11176596 · Data updated 2026-11-12
This study is working on new treatments that could help nerves heal better after injuries by creating small molecules that mimic a natural growth factor, which might lead to improved recovery for patients with nerve damage.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $72,100 |
| NIH project number | 3R21NS130471-01A1S1 |
| Project ID | NIH-11176596 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced traumatic nerve injuries and are seeking innovative treatment options.
✕Less likely to help
Patients with non-traumatic nerve conditions or those who do not have nerve injuries may not benefit from this research.
What this research studies
This research focuses on developing small molecule mimics of glial cell line-derived neurotrophic factor (GDNF) to enhance nerve regeneration after traumatic injuries. By creating compounds that can effectively bind to specific receptors involved in neuronal signaling, the project aims to improve the stability and effectiveness of treatments for nerve damage. The approach involves designing and testing these mimics to facilitate communication between cells, potentially leading to better outcomes in nerve repair. Patients may benefit from advancements in therapies that promote healing and recovery of the peripheral nervous system.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for nerve injuries, improving recovery and quality of life for affected patients.
How similar studies have gone: While there have been some studies on GDNF and its family ligands, the specific approach of using small molecule mimics for nerve regeneration is relatively novel and has not been extensively tested.
Where this research is happening
-
Texas A&m University
College Station, United States Active
Researchers
- Principal investigator: Burgess, Kevin — Texas A&m University
- Study coordinator: Burgess, Kevin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.