Using small molecules to enhance a virus treatment for melanoma
Harnessing the potential of pharmacological small molecules to amplify VSV-based oncolytic viral therapy
['FUNDING_R15'] · SOUTHERN UNIV A&M COL BATON ROUGE · NIH-10876187
This study is looking at how certain small drugs can help a virus treatment work better for melanoma, a serious skin cancer, by making it easier for the virus to attack and kill cancer cells, which could lead to improved results for patients.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SOUTHERN UNIV A&M COL BATON ROUGE (nih funded) |
| Locations | 1 site (BATON ROUGE, UNITED STATES) |
| Trial ID | NIH-10876187 on ClinicalTrials.gov |
What this research studies
This research investigates how small pharmacological molecules can improve the effectiveness of a virus-based therapy for melanoma, a deadly skin cancer. The approach focuses on inhibiting specific cellular pathways that cancer cells use to survive, allowing the oncolytic virus to better infect and kill these cancer cells. By studying this in a mouse model, the researchers aim to understand how to enhance the virus's ability to spread within tumors and induce cancer cell death, potentially leading to better treatment outcomes for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research would include patients diagnosed with malignant cutaneous melanoma who have limited treatment options.
Not a fit: Patients with non-melanoma skin cancers or those who have already received extensive treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for melanoma, improving survival rates and quality of life for patients.
How similar studies have performed: Previous research has shown promise in using oncolytic viruses for cancer treatment, suggesting that this approach could be a viable option for melanoma therapy.
Where this research is happening
BATON ROUGE, UNITED STATES
- SOUTHERN UNIV A&M COL BATON ROUGE — BATON ROUGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHAMCHEU, JEAN CHRISTOPHER — SOUTHERN UNIV A&M COL BATON ROUGE
- Study coordinator: CHAMCHEU, JEAN CHRISTOPHER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Cause, Cancer Etiology, Cancer Induction