Using SIRT3 to treat Alzheimer's disease
Activation of SIRT3 as a Therapeutic Strategy for Alzheimer's Disease
This study is looking at how a special enzyme called SIRT3 might help improve brain health and reduce inflammation in older veterans with Alzheimer's disease, to see if it can lead to better treatments for them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Eastern Colorado Health Care System NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11054494 on NIH RePORTER |
What this research studies
This research investigates the role of SIRT3, a deacetylase enzyme, in improving brain mitochondrial function and reducing neuroinflammation associated with Alzheimer's disease (AD). The study focuses on veterans aged 65 and older, who are at a higher risk for AD and often have additional health issues like diabetes and hypertension. By examining the effects of SIRT3 activation in a specially designed mouse model, the research aims to understand how enhancing this enzyme can reverse harmful changes in the brain that contribute to AD. The findings could lead to new therapeutic strategies for managing Alzheimer's disease in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are veterans aged 65 and older who are at risk for or diagnosed with Alzheimer's disease.
Not a fit: Patients younger than 65 or those without Alzheimer's disease or related cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a novel treatment approach that improves brain health and cognitive function in patients with Alzheimer's disease.
How similar studies have performed: Previous studies have shown promising results in targeting SIRT3 for metabolic and neurodegenerative conditions, suggesting potential for success in this novel application.
Where this research is happening
Aurora, UNITED STATES
- VA Eastern Colorado Health Care System — Aurora, United States (Active)
Researchers
- Principal investigator: Pugazhenthi, Subbiah — VA Eastern Colorado Health Care System
- Study coordinator: Pugazhenthi, Subbiah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.