Using SGLT2 inhibitors to improve blood vessel flexibility in older adults
Official title: SGLT2 inhibition as a therapeutic strategy to reverse arterial stiffening in aging
Funded at University of Missouri-Columbia · NIH-11093989 · Data updated 2026-11-12
This study is looking at how a type of medication called SGLT2 inhibitors might help make your blood vessels more flexible again, which can be a problem as we age and can lead to heart issues, especially for older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | June 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $591,486 |
| NIH project number | 5R01AG082413-02 |
| Project ID | NIH-11093989 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing arterial stiffness or related cardiovascular issues.
✕Less likely to help
Patients who are younger or do not have any signs of arterial stiffness or cardiovascular disease may not benefit from this research.
What this research studies
This research investigates how SGLT2 inhibitors can help reverse arterial stiffening, a common issue in aging that contributes to cardiovascular disease. The study aims to understand the molecular mechanisms behind arterial stiffening and how targeting these mechanisms can improve vascular health. By focusing on the role of vascular smooth muscle cells and their activation pathways, the research seeks to develop new therapeutic strategies to prevent or reverse cardiovascular complications in older adults.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cardiovascular health and reduce the risk of heart disease in older adults.
How similar studies have gone: Previous research has shown promising results in using similar approaches to target arterial stiffness, indicating potential for success in this area.
Where this research is happening
-
University of Missouri-Columbia
Columbia, United States Active
Researchers
- Principal investigator: Manrique Acevedo, Camila Margarita — University of Missouri-Columbia
- Study coordinator: Manrique Acevedo, Camila Margarita
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.