Using Satralizumab to treat complications from brain aneurysms.
Official title: Satralizumab as a Treatment for Aneurysmal Subarachnoid Hemorrhage (the STASH Trial)
Funded at University of Florida · NIH-10952347 · Data updated 2026-11-12
This study is looking at how well the drug Satralizumab can help people recover after a brain aneurysm by reducing complications like vasospasm, and it’s designed for patients who have had this type of hemorrhage.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | July 19, 2019 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $81,199 |
| NIH project number | 3R25NS108939-05S1 |
| Project ID | NIH-10952347 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who have recently experienced an aneurysmal subarachnoid hemorrhage and are at risk for vasospasm.
✕Less likely to help
Patients who have not experienced an aneurysmal subarachnoid hemorrhage or those with other unrelated neurological conditions may not benefit from this research.
What this research studies
This research investigates the use of Satralizumab, a drug that modulates the inflammatory response, to treat patients who have experienced an aneurysmal subarachnoid hemorrhage. The study aims to reduce vasospasm, a condition that can lead to severe complications after a brain aneurysm rupture. By assessing various biomarkers, behavioral outcomes, and imaging data, the research seeks to understand the drug's effectiveness in improving patient recovery and reducing long-term damage. This trial represents a significant step in translating laboratory findings into clinical practice.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment that significantly improves recovery and reduces complications for patients who suffer from aneurysmal subarachnoid hemorrhage.
How similar studies have gone: Previous research has shown promising results in modulating inflammatory responses in similar conditions, indicating potential for success in this novel approach.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Hoh, Brian Lim — University of Florida
- Study coordinator: Hoh, Brian Lim
Related research
Other NIH-funded projects on the same topics.
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Cognitive screening after an aneurysmal brain bleed
Using patient questionnaires to find thinking and memory problems in people recovering from aneurysmal subarachnoid hemorrhage.
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Molecularly mapping early brain injury after brain bleed using human brain organoids and patient CSF
Scientists are studying how early brain injury after aneurysmal subarachnoid hemorrhage happens in people, by using patient CSF and human brain organoids to find what signals cause damage and why women may have worse outcomes.
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Understanding metabolic changes after brain hemorrhage
This study is looking at how a serious brain condition called aneurysmal subarachnoid hemorrhage affects the body's metabolism and inflammation, with the goal of finding ways to predict how well patients will recover by analyzing blood samples.
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Identifying brain injury risks in patients with aneurysmal subarachnoid hemorrhage using brain activity monitoring.
This study is looking at how to better manage blood pressure for people who have had a brain bleed from an aneurysm, by closely monitoring their brain activity to find the best targets for blood flow, which could help prevent further complications and improve recovery.
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Improving cognitive assessment after brain hemorrhages for better patient outcomes
This study is looking to improve how we spot and understand thinking problems in people who have had a brain bleed, especially focusing on African American and rural patients who might not get the help they need, so we can help them live better lives.
-
Blood test to predict delayed brain injury after an aneurysm bleed
This project is creating a blood test to spot which people who had a brain aneurysm bleed are likely to develop delayed brain injury in the days after the bleed.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.