Using Salmonella nanoparticles to enhance cancer immunotherapy
Salmonella derived nanoparticles for cancer immunotherapy
This study is exploring how tiny particles made from Salmonella can help boost the immune system's fight against HPV-related head and neck cancer, making it easier for the body to target and attack cancer cells.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11035857 on NIH RePORTER |
What this research studies
This research investigates the use of Salmonella-derived nanoparticles to improve cancer immunotherapy, particularly for HPV-associated head and neck cancer. The approach focuses on enhancing the immune response by utilizing genetically modified proteins that can effectively stimulate dendritic cells, which are crucial for activating CD8+ T cells that target tumors. By creating longer-lasting forms of these proteins, the study aims to improve the body's ability to generate a strong and localized immune response against cancer cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with HPV-associated head and neck cancer who are seeking innovative treatment options.
Not a fit: Patients with non-HPV-related cancers or those who are not eligible for immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and less harmful treatments for patients with HPV-associated head and neck cancer.
How similar studies have performed: Other research has shown promise in using nanoparticles for cancer immunotherapy, indicating that this approach may have a strong potential for success.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Hung, Chien-Fu — Johns Hopkins University
- Study coordinator: Hung, Chien-Fu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.