Using saliva to find early signs of Alzheimer's disease and related disorders
Salivary Extracellular Vesicles as Biomarkers for Alzheimer's Disease and Related Disorders
This study is looking at how tiny particles in saliva could help us spot early signs of Alzheimer's and similar conditions, making it easier and less invasive for people to find out if they're at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-11056883 on NIH RePORTER |
What this research studies
This research investigates the use of salivary extracellular vesicles as potential biomarkers for Alzheimer's disease and related disorders. The goal is to develop a non-invasive method to identify individuals at risk of developing these conditions, which include Alzheimer's, frontotemporal dementia, and others. By analyzing saliva samples, researchers aim to discover easily accessible biomarkers that can be used in clinical settings to detect early signs of disease, potentially allowing for earlier intervention. This approach seeks to overcome the limitations of current diagnostic methods that are often invasive or costly.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk for Alzheimer's disease or related disorders, particularly those in the preclinical stage of the disease.
Not a fit: Patients who are already diagnosed with advanced Alzheimer's disease or related disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a simple saliva test that helps identify individuals at risk for Alzheimer's disease and related disorders much earlier than current methods allow.
How similar studies have performed: While there has been some success with blood-based biomarkers for Alzheimer's, the use of salivary biomarkers is still a novel approach that has not been extensively tested.
Where this research is happening
Providence, United States
- Brown University — Providence, United States (Active)
Researchers
- Principal investigator: Kreiling, Jill — Brown University
- Study coordinator: Kreiling, Jill
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.