Using saline evaporation to cool organs during stroke treatment
Official title: Harnessing the latent heat of saline evaporation for safe and effective endovascular therapeutic organ cooling
Funded at Mayo Clinic Rochester · NIH-10739142 · Data updated 2026-11-12
This study is exploring a new way to cool the brain during stroke treatment to help protect it from damage, especially for patients with severe blockages, by using evaporating saline, which could make a big difference during their procedure.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | July 15, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $443,850 |
| NIH project number | 1R21NS130297-01A1 |
| Project ID | NIH-10739142 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients experiencing ischemic strokes, particularly those with large vessel occlusions who are undergoing thrombectomy.
✕Less likely to help
Patients who are not experiencing an ischemic stroke or those who do not qualify for thrombectomy may not benefit from this research.
What this research studies
This research investigates a novel method to cool the brain during stroke treatment by harnessing the latent heat of saline evaporation. The approach aims to improve outcomes for patients undergoing thrombectomy for ischemic strokes, particularly those with large vessel occlusions. By cooling the brain tissue during the procedure, the research seeks to protect neurons from damage caused by reduced blood flow. This method could potentially be implemented immediately during the thrombectomy, maximizing the cooling effect on vulnerable brain areas.
Why it matters
Potential benefit: If successful, this research could lead to improved functional outcomes for stroke patients by reducing neuronal injury during treatment.
How similar studies have gone: Previous research has shown promise in using hypothermia as a neuroprotectant during stroke treatment, indicating that this approach could be a significant advancement.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Kallmes, David F — Mayo Clinic Rochester
- Study coordinator: Kallmes, David F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.