Using Romosozumab to Improve Bone Health in People with Chronic Spinal Cord Injury
Official title: Romosozumab to Improve Bone Mineral Density and Architecture in Chronic SCI
Funded at James J Peters VA Medical Center · NIH-11092804 · Data updated 2026-11-12
This study is looking at how a new treatment with Romosozumab can help people with chronic spinal cord injuries build stronger bones and reduce the risk of fractures, making it easier for them to stay active and enjoy daily life.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James J Peters VA Medical Center NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | June 1, 2020 |
| Project end | June 30, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01RX003415-06 |
| Project ID | NIH-11092804 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with chronic spinal cord injury who are experiencing significant bone loss.
✕Less likely to help
Patients without chronic spinal cord injury or those who do not have significant bone density issues may not benefit from this research.
What this research studies
This research investigates the effects of a dual pharmacological intervention, including Romosozumab, on improving bone mineral density and architecture in individuals with chronic spinal cord injury (SCI). The study aims to restore bone mass below the level of injury, which could help reduce the risk of low-impact fractures and enhance the ability to engage in daily activities. By increasing bone turnover, the research seeks to promote bone formation over resorption, potentially leading to better overall bone health and quality of life for participants. The approach is based on promising preclinical findings that showed significant improvements in bone density and structure in animal models.
Why it matters
Potential benefit: If successful, this research could significantly improve bone health and reduce fracture risk for individuals with chronic spinal cord injury.
How similar studies have gone: Previous research has shown success in improving bone density in animal models with similar pharmacological approaches, indicating potential for positive outcomes in human subjects.
Where this research is happening
-
James J Peters VA Medical Center
Bronx, United States Active
Researchers
- Principal investigator: Cardozo, Christopher P — James J Peters VA Medical Center
- Study coordinator: Cardozo, Christopher P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.