Using RNA aptamers to understand and control blood clotting
RNA Aptamers as Probes and Modulators of Coagulation
['FUNDING_P01'] · CHILDREN'S HOSP OF PHILADELPHIA · NIH-10768831
This study is working on creating special molecules that can help us understand and control how blood clots, which could lead to better treatments for people with blood clotting issues.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S HOSP OF PHILADELPHIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10768831 on ClinicalTrials.gov |
What this research studies
This research focuses on developing RNA aptamers to explore the interactions that regulate blood coagulation. By utilizing advanced techniques like high-resolution X-ray crystallography, the team aims to create innovative agents that can effectively modulate coagulation processes. These agents are designed to be potent yet reversible, allowing for precise control in both research and clinical settings. The ultimate goal is to enhance our understanding of blood clotting mechanisms and improve treatment options for related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to abnormal blood coagulation, such as hemophilia or thrombosis.
Not a fit: Patients who do not have coagulation disorders or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for managing blood coagulation disorders, improving patient outcomes.
How similar studies have performed: Previous research has shown promise in using similar approaches to develop anticoagulant therapies, indicating potential for success in this area.
Where this research is happening
PHILADELPHIA, UNITED STATES
- CHILDREN'S HOSP OF PHILADELPHIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SULLENGER, BRUCE ALAN — CHILDREN'S HOSP OF PHILADELPHIA
- Study coordinator: SULLENGER, BRUCE ALAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.