Using resistance exercise to protect older adults from muscle damage caused by glucocorticoids
Resistance exercise for protection against glucocorticoids in aged skeletal muscle
This study is looking at how strength training can help older adults keep their muscles strong and healthy, especially when they are taking medications like glucocorticoids that can cause muscle weakness.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida State University NIH-funded |
| Lab location | 1 site (Tallahassee, United States) |
| Project ID | NIH-10615777 on NIH RePORTER |
What this research studies
This research investigates how resistance exercise can help protect the muscles of older adults from damage caused by glucocorticoids, which are often used to treat conditions like arthritis and cancer. The study focuses on understanding the mechanisms behind glucocorticoid myopathy, a condition that leads to muscle weakness and atrophy in the elderly. By examining the effects of resistance exercise on muscle cells, the researchers aim to determine if this type of exercise can reduce harmful changes in muscle function associated with glucocorticoid treatment. The findings could provide insights into effective strategies for maintaining muscle health in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are receiving glucocorticoid therapy for conditions such as arthritis or cancer.
Not a fit: Patients who are not on glucocorticoid therapy or who are younger and not experiencing muscle atrophy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new exercise-based interventions that help older adults maintain muscle strength and function while undergoing glucocorticoid treatment.
How similar studies have performed: Previous research has shown that resistance exercise can mitigate muscle damage in younger populations, suggesting potential for similar benefits in older adults, although this specific approach is still being explored.
Where this research is happening
Tallahassee, United States
- Florida State University — Tallahassee, United States (Active)
Researchers
- Principal investigator: Gordon, Bradley S — Florida State University
- Study coordinator: Gordon, Bradley S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.