Using resistance exercise to help prevent muscle problems in Alzheimer's patients
Official title: Resistance exercise to mitigate glucocorticoid myopathy during Alzheimer’s
Funded at Florida State University · NIH-10808941 · Data updated 2026-11-12
This study is looking at how strength training can help people with Alzheimer's who have muscle problems caused by certain stress hormones, to see if it can improve their muscle health and possibly slow down memory loss.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida State University NIH-funded |
| Lab location | 1 site (Tallahassee, United States) |
| Project start | March 15, 2023 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $74,332 |
| NIH project number | 5R03AG078886-02 |
| Project ID | NIH-10808941 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease who are experiencing muscle weakness or deterioration.
✕Less likely to help
Patients who do not have Alzheimer's disease or those without muscle health issues may not benefit from this research.
What this research studies
This research investigates how resistance exercise can help Alzheimer's patients who are experiencing muscle issues due to high levels of glucocorticoids. The study aims to determine if engaging in resistance training can reduce the harmful effects of glucocorticoids on muscle health, which in turn may help slow cognitive decline. By examining the biological responses of muscle to exercise, the research seeks to identify mechanisms that could protect against muscle deterioration in this population. Patients participating in this research may engage in structured exercise programs designed to improve their muscle function and overall health.
Why it matters
Potential benefit: If successful, this research could provide a new therapeutic approach to preserve muscle health and cognitive function in Alzheimer's patients.
How similar studies have gone: Previous research has shown that exercise can have beneficial effects on muscle health in various populations, suggesting potential success for this approach in Alzheimer's patients.
Where this research is happening
-
Florida State University
Tallahassee, United States Active
Researchers
- Principal investigator: Gordon, Bradley S — Florida State University
- Study coordinator: Gordon, Bradley S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.