Using resistance exercise to help prevent and treat heart failure with preserved ejection fraction.
Official title: Resistance Exercise in the Prevention and Treatment of Heart Failure with Preserved Ejection Fraction (HFpEF)
Funded at University of Minnesota · NIH-10862959 · Data updated 2026-11-12
This study is looking at how strength training can help people with heart failure feel better and stay active, making it easier for them to stick to their exercise routines.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | September 9, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $117,789 |
| NIH project number | 1K99HL173668-01 |
| Project ID | NIH-10862959 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with heart failure with preserved ejection fraction who may benefit from tailored exercise programs.
✕Less likely to help
Patients with heart failure who do not have preserved ejection fraction or those unable to participate in exercise may not benefit from this research.
What this research studies
This research investigates how resistance exercise can be used as a strategy to prevent and treat heart failure with preserved ejection fraction (HFpEF). It aims to improve patient adherence to exercise regimens, which is crucial given the challenges of physical inactivity and obesity. The study will explore biological pathways that connect exercise to heart health, providing insights into how resistance training can benefit patients with HFpEF. The research is led by Dr. McDonough at the University of Minnesota, utilizing a strong mentorship team and institutional resources.
Why it matters
Potential benefit: If successful, this research could lead to more effective exercise-based interventions for patients with heart failure, improving their quality of life and health outcomes.
How similar studies have gone: Previous research has shown that exercise can be beneficial for heart failure patients, but this specific focus on resistance exercise in HFpEF is relatively novel.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Mcdonough, Dj — University of Minnesota
- Study coordinator: Mcdonough, Dj
Related research
Other NIH-funded projects on the same topics.
-
AI-supported heart failure diagnosis and management in Rwanda
Aiming to help people with suspected heart failure in Rwanda get faster, more accurate diagnoses and better care using AI-guided ultrasound and care protocols.
-
AI-assisted heart failure diagnosis in Rwanda using focused ultrasound
An NIH-funded project will test whether AI-enhanced, easy-to-use heart ultrasound can help non-experts diagnose and manage heart failure in Rwanda.
-
HF endotypes in heart failure using ethical multi-modal AI and molecular data
A patient-friendly project that uses advanced AI and multiple kinds of health data to identify distinct heart failure subtypes that could guide personalized care.
-
Triple gene therapy approach to heal the heart after a heart attack
A new therapy combines three genetic approaches delivered by a virus to help the heart heal after a heart attack.
-
Digital-first heart failure care delivery in Uganda
A targeted program in Uganda tests a digital care plan to help people with heart failure manage their symptoms at home.
-
Digital-first heart failure care delivery in Uganda
A study to test digital self-care tools to help people with heart failure in Uganda manage symptoms and stay healthier.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.