Using resistance exercise to help prevent and treat heart failure with preserved ejection fraction.

Resistance Exercise in the Prevention and Treatment of Heart Failure with Preserved Ejection Fraction (HFpEF)

NIH-funded research University of Minnesota · NIH-10862959

This study is looking at how strength training can help people with heart failure feel better and stay active, making it easier for them to stick to their exercise routines.

Quick facts

Grant typeCareer grant
Study typeNIH-funded research
Funding institutionUniversity of Minnesota NIH-funded
Lab location1 site (Minneapolis, United States)
Project IDNIH-10862959 on NIH RePORTER

What this research studies

This research investigates how resistance exercise can be used as a strategy to prevent and treat heart failure with preserved ejection fraction (HFpEF). It aims to improve patient adherence to exercise regimens, which is crucial given the challenges of physical inactivity and obesity. The study will explore biological pathways that connect exercise to heart health, providing insights into how resistance training can benefit patients with HFpEF. The research is led by Dr. McDonough at the University of Minnesota, utilizing a strong mentorship team and institutional resources.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals diagnosed with heart failure with preserved ejection fraction who may benefit from tailored exercise programs.

Not a fit: Patients with heart failure who do not have preserved ejection fraction or those unable to participate in exercise may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to more effective exercise-based interventions for patients with heart failure, improving their quality of life and health outcomes.

How similar studies have performed: Previous research has shown that exercise can be beneficial for heart failure patients, but this specific focus on resistance exercise in HFpEF is relatively novel.

Where this research is happening

Minneapolis, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.