Using reovirus to stimulate the immune system in colorectal cancer with KRAS mutations
Official title: Autophagy mediated immune stimulation by reovirus in KRAS mutated colorectal cancer
Funded at Yeshiva University · NIH-10359958 · Data updated 2026-11-12
This study is looking at how a virus called reovirus might help boost the immune system in people with colorectal cancer that has specific mutations, which can make the cancer harder to treat, with the hope of finding new ways to improve treatment for these patients.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yeshiva University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 14, 2022 |
| Project end | December 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $433,953 |
| NIH project number | 1R15CA267835-01 |
| Project ID | NIH-10359958 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with colorectal cancer that has KRAS mutations and who have limited treatment options.
✕Less likely to help
Patients with colorectal cancer that does not have KRAS mutations may not benefit from this research.
What this research studies
This research investigates how reovirus, a virus with a double-stranded RNA genome, can stimulate the immune system in patients with colorectal cancer that has KRAS mutations. These tumors often evade immune detection, making treatment challenging. The study aims to understand how reovirus induces autophagy and enhances immune responses in these tumors, potentially leading to new therapeutic strategies. By exploring the interaction between immune and autophagic pathways, the research seeks to uncover mechanisms that could improve treatment outcomes for affected patients.
Why it matters
Potential benefit: If successful, this research could provide a novel treatment option for patients with KRAS mutated colorectal cancer, enhancing their immune response against tumors.
How similar studies have gone: While reovirus has shown promise in previous studies for its oncolytic properties, this specific approach to enhance immune stimulation in KRAS mutated tumors is relatively novel and has not been extensively tested.
Where this research is happening
-
Yeshiva University
New York, United States Active
Researchers
- Principal investigator: Maitra, Radhashree — Yeshiva University
- Study coordinator: Maitra, Radhashree
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.