Using remote ischemic conditioning to help recovery after brain hemorrhage
Official title: Remote ischemic Conditioning Promotes Cerebrovascular Recovery after Intracerebral Hemorrhage
Funded at Augusta University · NIH-10928088 · Data updated 2026-11-12
This study is looking at how a special treatment called remote ischemic conditioning might help people recover better after a serious type of stroke called intracerebral hemorrhage by promoting healing in the brain and improving brain function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | September 1, 2020 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $380,942 |
| NIH project number | 5R01NS117565-05 |
| Project ID | NIH-10928088 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have recently suffered an intracerebral hemorrhage and are seeking innovative treatment options for recovery.
✕Less likely to help
Patients who have not experienced an intracerebral hemorrhage or those with other types of strokes may not benefit from this research.
What this research studies
This research investigates the effects of remote ischemic conditioning (RIC) on recovery following intracerebral hemorrhage (ICH), a severe type of stroke. By applying brief periods of controlled ischemia to a limb, the study aims to promote vascular repair and improve neurological function in patients who have experienced ICH. The approach focuses on understanding how RIC activates specific immune cells that may aid in healing and restoring blood flow in the brain. Participants will be monitored for improvements in brain function and overall recovery.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly enhance recovery and quality of life for patients after a brain hemorrhage.
How similar studies have gone: Previous studies have shown promising results with remote ischemic conditioning in other contexts, suggesting potential for success in this novel application.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Dhandapani, Krishnan M. — Augusta University
- Study coordinator: Dhandapani, Krishnan M.
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This project will test whether blocking a protein called HDAC3 can reduce inflammation and improve recovery after an intracerebral hemorrhage (brain bleed).
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.