Using real-world data to improve cancer treatment precision
Official title: Leveraging Observational (Real World) Data to Advance Precision Oncology
Funded at Sloan-Kettering Inst Can Research · NIH-10768974 · Data updated 2026-11-12
This study is looking to improve cancer treatment by understanding why people with the same genetic mutations respond differently to medications, and it aims to make sure everyone has fair access to the best care, using data from a large group of cancer patients around the world.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 3, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $2,372,456 |
| NIH project number | 1P01CA275746-01A1 |
| Project ID | NIH-10768974 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include cancer patients with specific genetic mutations who are seeking personalized treatment options.
✕Less likely to help
Patients with cancers that do not have identified genetic mutations or those not seeking precision oncology treatments may not benefit from this research.
What this research studies
This research aims to enhance precision oncology by addressing challenges such as varied responses to cancer drugs among patients with the same genetic mutations and differences in mutation frequencies across ethnic groups. The team will analyze a large international cancer registry, AACR Project GENIE, which includes data from over 148,000 patients. By leveraging observational data, the research will explore how to optimize cancer treatment and ensure equitable access to precision diagnostics. The approach includes four integrated projects focusing on methodological improvements, genetic ancestry impacts, and real-world evidence.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized cancer treatments for patients.
How similar studies have gone: Previous research has shown promise in using real-world data to inform cancer treatment strategies, indicating that this approach could yield valuable insights.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Sawyers, Charles L. — Sloan-Kettering Inst Can Research
- Study coordinator: Sawyers, Charles L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.