Using real-world cancer data to improve personalized cancer care
Leveraging Observational (Real World) Data to Advance Precision Oncology
['FUNDING_P01'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-11181536
Researchers will use a very large international collection of clinical and tumor-genetic records to make personalized cancer treatments work better for people with cancer.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11181536 on ClinicalTrials.gov |
What this research studies
If you take part, researchers will combine and analyze a very large international database of clinical records and tumor genetic tests (AACR Project GENIE) that already includes over 148,000 patients. They will develop better statistical and bioinformatics methods to make sense of observational 'real-world' data and study how genetic ancestry affects mutation frequencies and treatment responses. The team will use these real-world findings to guide treatment choices for patients who aren't well served by conventional clinical trials and will improve how results are reported so clinicians can use them reliably. Work spans methodological development, analyses of patient tumor and clinical records, and multi-center collaboration to increase representation across ethnic groups.
Who could benefit from this research
Good fit: People with cancer who have had tumor genomic testing and are willing to allow use of their de-identified clinical and genetic records, especially patients from underrepresented ethnic groups, are most relevant.
Not a fit: Patients without available tumor genomic data, those who do not want their records shared, or those with tumor types not represented in the registry may not see direct benefits.
Why it matters
Potential benefit: If successful, this work could help doctors choose targeted therapies more accurately, reduce ancestry-related treatment disparities, and expand options for patients with rare tumor subtypes.
How similar studies have performed: Large clinico-genomic registries like AACR Project GENIE have already produced important insights, but applying real-world data to guide individual treatment decisions is still new and being refined.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SAWYERS, CHARLES L. — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: SAWYERS, CHARLES L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: American Association of Cancer Research, Cancer Center, Cancer Genes, Cancer Patient