Using rare genetic causes to improve understanding and treatment of neuropsychiatric disorders
Official title: Leveraging rare genetic etiologies to advance knowledge and treatment of neuropsychiatric disorders
Funded at Geisinger Clinic · NIH-10597665 · Data updated 2026-11-12
This study is looking at how rare genetic disorders might affect mental health conditions like schizophrenia, bipolar disorder, and autism, and it's for people with unique genetic profiles who want to help us understand how these genes influence symptoms and treatment options.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Geisinger Clinic NIH-funded |
| Lab location | 1 site (Danville, United States) |
| Project start | June 10, 2019 |
| Project end | March 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $1,826,721 |
| NIH project number | 5U01MH119705-05 |
| Project ID | NIH-10597665 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with neuropsychiatric disorders who have rare genetic etiologies.
✕Less likely to help
Patients without a diagnosed neuropsychiatric disorder or those with common genetic profiles may not benefit from this research.
What this research studies
This research investigates how rare genetic disorders contribute to neuropsychiatric conditions like schizophrenia, bipolar disorder, and autism. By leveraging advanced genomic technologies, the study aims to identify and characterize the genetic factors that influence these disorders. Researchers will recruit individuals with rare genetic profiles from large clinical populations to better understand the variability in symptoms and outcomes. The goal is to establish a clearer link between genetics and neuropsychiatric symptoms, potentially leading to improved treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments tailored to the genetic profiles of patients with neuropsychiatric disorders.
How similar studies have gone: Previous research has successfully used similar genetic approaches to advance understanding and treatment in other medical fields, suggesting potential for success in this area as well.
Where this research is happening
-
Geisinger Clinic
Danville, United States Active
Researchers
- Principal investigator: Martin, Christa Lese — Geisinger Clinic
- Study coordinator: Martin, Christa Lese
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.